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The MOTHER of all GUT Posts? GPR43 (FFAR2) TLR's B-vits = LONG LIFE
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randall  
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 More options 6 Nov, 21:39
Newsgroups: alt.support.skin-diseases.psoriasis
From: randall <ranhu...@aol.com>
Date: Fri, 6 Nov 2009 13:39:54 -0800 (PST)
Local: Fri 6 Nov 2009 21:39
Subject: The MOTHER of all GUT Posts? GPR43 (FFAR2) TLR's B-vits = LONG LIFE

Hi,

What's the biggest thing today right now in your yin/yang?

That's right.

The uroborus BM of them ALL... :)

What?

What are you talking about?

Elementary or in this case "Alimentary MY DEAR WATSON".....

This is another randallific uroboric moment?

U said it...

As in that snake who doesn't want you to eat the fiber rich aPPle in
eden?

What?

OK, then.

That snake who wants you to eat your tail, or his tail?

http://en.wikipedia.org/wiki/Ouroboros

So how does this alimenatarian Adam and Eve live forever east of EDEN?

EASY as aPPle Pie...

Did any of you read about GPR43 in a recent thread or two?

GPR43 really is almost as big as some others recently, like SFB & L.
Plantarum come to mind.

So what is it?

From wikipedia?

Yes make it short and sweet, like your whey.

OK...

http://en.wikipedia.org/wiki/Free_fatty_acid_receptor
The free fatty acid receptor is a G-protein coupled receptor which
binds free fatty acids.[1] There are four variants of the receptor,
each encoded by a separate gene (FFAR1, FFAR2, FFAR3, GPR42).

Huh?

GPR43 is really FFAR2?

How about that? LOL

http://www.genenames.org/data/hgnc_data.php?match=FFAR2

So ok already let's see what's what with FFAR2 which is GPR43.

The science (pubmed--abstract) answer contains words like ileum. LOL

So Susan don't read this and skip to the articles. :)

http://www.ncbi.nlm.nih.gov/pubmed/16453106
Short-chain fatty acid receptor, GPR43, is expressed by
enteroendocrine cells and mucosal mast cells in rat intestine.

Karaki S, Mitsui R, Hayashi H, Kato I, Sugiya H, Iwanaga T, Furness
JB, Kuwahara A.

Laboratory of Physiology, Institute for Environmental Sciences,
University of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan.

Short-chain fatty acids (SCFAs), such as acetate, propionate, and
butyrate, are the major anions in the large intestinal lumen. They are
produced from dietary fiber by bacterial fermentation and are known to
have a variety of physiological and pathophysiological effects on the
intestine. In the present study, we investigated the expression of the
SCFA receptor, GPR43, in the rat distal ileum and colon. Expression of
GPR43 was detected by reverse transcriptase/polymerase chain reaction
(RT-PCR), Western blotting, and immunohistochemistry. mRNA for GPR43
was detected, by RT-PCR, in extracts of the whole wall and separated
mucosa from the ileum and colon and from muscle plus submucosa from
the ileum, but not from muscle plus submucosa preparations from the
colon. We raised a rabbit antiserum against a synthesized fragment of
rat GPR43; this was specific for rat GPR43. GPR43 protein was detected
by Western blot analysis in extracts of whole wall and separated
mucosa, but not in muscle plus submucosa extracts. By
immunohistochemistry, GPR43 immunoreactivity was localized to
enteroendocrine cells expressing peptide YY (PYY), whereas 5-
hydroxytryptamine (5-HT)-immunoreactive (IR) enteroendocrine cells
were not immunoreactive for GPR43. Mast cells of the lamina propria
expressing 5-HT were also GPR43-IR. The results of the present study
suggest that the PYY-containing enteroendocrine cells and 5-HT-
containing mucosal mast cells sense SCFAs via the GPR43 receptor. This
is consistent with physiological data showing that SCFAs stimulate the
release of PYY and 5-HT from the ____ileum____ and colon.

PMID: 16453106

Why is it, that your ileum is important?  Not to long ago JRSTERN was
posting
stuff for your appendix and eight years ago JR posted the GOOD ARTICLE
link
from XOMA that no longer works but was posted in full in this group.

The GOOD ARTICLE clued some of in to LPS and what it does in your
colon.

Then we found out about TLR's (toll like receptors)

Since then I've never looked back. :)

I knew this was the right track. It had to be.

And if i waited the science would catch up to my trials
that cleared my skin with the wit kit and sweet whey diet.

OK, ok...

First lets see what this science and GPR43 in your colon and ileum is
all about.

I'll repost the recent links:

This was on oct 30 2009 or less then a week ago.

http://www.eurekalert.org/pub_releases/2009-10/ra-nfc102809.php
New findings connect diet and intestinal bacteria with healthier
immune systems
<sniP>

And from byron's article i posted yesterday:
http://www.wellnessresources.com/health/articles/how_fiber_friendly_f...

This one is so good you should read byrons notes:
http://www.wellnessresources.com/studies/entry/fiber_and_friendly_flo...
This looks like the same link. So go to the link in the article and in
blue
it says " dietary fiber and friendly GI tract flora" and click it
and you'll get byrons notes on this topic.

==========================================

This next B vitamin Article is for Susan and others who want to LIVE
long and prosPer.

Like a vulcan?

Sure or here on earth like Methuselah grand-father of Noah who
invented red wine. LOL

NO>?

Really?

Wiki says so. So it must be.

http://en.wikipedia.org/wiki/Methuselah
Methuselah was the grandfather of Noah and the oldest person whose age
is mentioned in the Hebrew Bible, given as 969 years
The name Methuselah has become a general synonym for any living
creature of great age.

http://en.wikipedia.org/wiki/Noah

[...]
"Noah was the first tiller of the soil. He planted a vineyard; and he
drank of the wine."[10]

Noah died 350 years after the Flood, at the age of 950,[11] the last
of the immensely long-lived antediluvian Patriarchs. The maximum human
lifespan, as depicted by the Bible, diminishes rapidly thereafter,
from as much as 900 years to the 120 years of Moses within twenty
generations. Another few generations later, lifespans were reported to
be less than 100 years on average.
<sniP>

http://en.wikipedia.org/wiki/Noah#Textual_criticism

[...]
Genesis seems to contain two accounts concerning Noah, the first
making him the hero of the Flood, the second representing him as a
husbandman who planted a vineyard. This has led some scholars to
believe that Noah was believed by the ancients to be the inventor of
wine, in keeping with the statement at Genesis 5:29 that Lamech
"called his name Noah, saying, 'Out of the ground which the Lord has
cursed this one shall bring us relief from our work and from the toil
of our hands.'"[18]
<sniP>

See third paragraph:
http://en.wikipedia.org/wiki/Noah#Connections_to_other_lore

Wow--->  did Ham sodomize his dad while drunk on wine?
http://en.wikipedia.org/wiki/Ham,_son_of_Noah

read genesis 20-25
http://www.mechon-mamre.org/p/pt/pt0109.htm#20

&
http://en.wikipedia.org/wiki/Ham,_son_of_Noah#Curse_of_Canaan_also_kn...

I love this biblicow stuff.

Wine, and God, what's not to like?

Here's another:

This was a really fun read by Larry Williams in another Godly vein.

Moses and where did he park after leaving Town.

"The mountain of Moses discovery of mount sinai: (book) by larry
williams
You can buy one here:
http://www.alibris.com/booksearch?qwork=4484495&matches=21&author=Wil...

Larry had a blast doing this book and the RESEARCH for it.

In his __work__ life, he's found a great measure of success that he
shares:
http://www.ireallytrade.com/

While Larry Makes the big bucks your health is still your greatest
WEALTH.

================

How do we find it?

Wowser, take a tiP already.

It's a gut trip with red wine or those cool longevinex capsules.

Now---> red wine in a capsule can be had from www.longevinex.com
without
Ham pulling the BONE on you while skunk drunk.  LOL

I never knew this Canaan curse. See fifth paragraph till end:
http://en.wikipedia.org/wiki/Canaan#Biblical_Canaanites

How do we avoid the curse in OUR bodies?

Easy....

Just take the alcohol free www.longevinex.com capsules and block
the sugar, sugar, honey, honey problems with B vits.

How amazing? Which ones?

http://www.vrp.com/articles.aspx
Can a Single Vitamin Prevent Premature Aging?

By VRP Staff

  Believe it or not, your body is producing poisons at this very
moment. And while they may be a natural part of aging, they’re also
very, very damaging. In fact, advanced glycation end products (AGEs)—
toxic molecules formed through a series of haywire reactions between
sugar, proteins and lipids—are directly involved in just about every
disease of aging imaginable.1–11

Research shows that, among diabetics, AGEs are the main culprit behind
aging that’s accelerated a full 20 to 40 years faster than non–
diabetics—taking the form of conditions like arterial plaque and
hardening of arteries, kidney disease, retinopathy and peripheral
nerve damage.12 But even non–diabetics need to watch out for these
dangerous byproducts, as your levels only increase with age, and pave
the way to any number of other serious diseases—including Alzheimer’s
disease, arthritis and macular degeneration.

The good news is that there’s a way to block and even reverse the
damage these AGEs can cause—and a single B vitamin may be your secret
weapon.13

In recent years, scientists have discovered that benfotiamine—a
synthetic, fat–soluble form of thiamine, or vitamin B1—is a potent AGE
blocker. In fact, clinical studies show that this form of the vitamin
is as much as 430 percent more bioavailable than its water–soluble
counterpart, which has a modest absorption rate of only four to six
percent.14–16

This superior absorption rate offers one reason for the powerful
protection benfotiamine offers against AGEs—a benefit that’s been
borne out in a number of animal and human studies. In one study, for
example, researchers found that type 1 diabetics given 600 mg of
benfotiamine daily experienced a 40 to 62 percent drop in just four
weeks of levels of carboxymethyllysine (CML) and methylglyoxal — two
predominant AGEs implicated in Alzheimer’s disease, blood vessel
complications and atherosclerosis.17

Further trials show that supplementing with ...

read more »


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JRStern  
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 More options 7 Nov, 00:26
Newsgroups: alt.support.skin-diseases.psoriasis
From: JRStern <JRSt...@foobar.invalid>
Date: Fri, 06 Nov 2009 16:26:40 -0800
Local: Sat 7 Nov 2009 00:26
Subject: Re: The MOTHER of all GUT Posts? GPR43 (FFAR2) TLR's B-vits = LONG LIFE
On Fri, 6 Nov 2009 13:39:54 -0800 (PST), randall <ranhu...@aol.com>
wrote:

>randall.... isn't it all stunning?   I think SO.. :)

Yes, I think so too.

The GPR43 sounds hot ... but can't we just swallow some short chain
fatty acids and skip the flora?  And I guess they mean *really* short
chain fatty acids ... acetate?

And maybe the benfotiamine is 400% more absorbable, but 2000%
B-complex pills are a penny each.

And maybe I should go get some.

Still, it is exciting to see some mainline research looking at these
things and finding results.

J.


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randall  
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 More options 9 Nov, 02:37
Newsgroups: alt.support.skin-diseases.psoriasis
From: randall <ranhu...@aol.com>
Date: Sun, 8 Nov 2009 18:37:28 -0800 (PST)
Local: Mon 9 Nov 2009 02:37
Subject: Re: The MOTHER of all GUT Posts? GPR43 (FFAR2) TLR's B-vits = LONG LIFE
On Nov 6, 4:26 pm, JRStern <JRSt...@foobar.invalid> wrote:

J,

What do you think?  I haven't done the work on fatty acids?

What about w3?  How short is it compared to 6, 9, 12 hike?

How many omega-3 threads in our group?

716 hits for keyword: omega-3  [in the psor news group]
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/se...

But why stop there?

I really REALLY like'd the benfotiamine (artificial B1) article.

We've had six hits TOTAL in the psor group for benfotiamine.

That;s it?

Yes...

AS opposed to way over 700 hits for omega-3's.

Why is that?  We should really look at AGE's more.

And one of those may look rather familiar to YOU. <W>

http://groups.google.com/group/alt.support.skin-diseases.psoriasis/ms...

That's right.

You hooked up with synthetic Vit B1 back on FEB 16 2003 in our group.
LOL

How prescient are you?  <G>  ;~/

And how prescient AM i?

Only as prescient as google allows me. LOL

Further down in the same thread to evetsm:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/ms...

Wow i'm reading me from six years ago and i'm smarter then then, NOW.

How can that be?

Easy... i need more B-1. LOL

And look at this anti pharma post in a similar B1 thread:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/ms...

Holy Ghost. This is so weird to revisit the ghost of fumaderm.

And how COME we're not privy to FAE;s right now?

I'll tell you why. Because big Pharma is not going to let us use
anything that will intrude on their bio illogical pot of gold....

Biologicals are simply so elementary compared to the places and genes
we've
seen in the last few weeks, it's UNreal...

And living longer for psoriatics is the single most important area
i'm now researching. :)

After SFB's and L. Plantarum and those genes in our pathways i'm
thinking living till mid 90's and doing it with my brain cells still
intact.

And all because of a benfotiamine group search:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/se...

----------

What I ALSO liked i this thread was the biblical apple references,
besides the red wine cites.

Apples and red wine and living for over a 100 years. Yikes...

How much do i like it?

Tons..

I've posted way to much on resveratrol (from: www.longevinex.com  --
red wine or japanese knot weed) and not enough on aPPles.

APPles are loaded with quercetin:
http://en.wikipedia.org/wiki/Quercetin

The only foods loaded with more are capers and lovage.

When are you gonna swill those two down, when you can easily nail a
few apples a day? LOL

I"m using capers in my sweet whey shakes NOW....

I'm gonna live AT THE VERY LEAST LONG ENOUGH FOR THE CURE OF
PSORIASIS.

And when we can muster the CD4+CD25+ regulatory T (Treg) cells and
attenuate Th17
in a timely manner to stay clear, i'll say hip hip hooray.

Why?

Because then i'll know i'm clear.

Why?

Just look stuPid.

156 hits for keywords: CD4+CD25+ regulatory T (Treg) cells [in our
psor support group]
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/se...

Isn't that cool?

I think so.

With the most recent posts i'm so Jazzed it's not funny.

My OCD is paying off. LOL

And my Chargers beat the Giants in a less second thriller today.

21-20 with 20 seconds left on the clock.

Btw- sorry your LA team couldn't beat the New York team.

Now i'm worried my chargers may be coming back home
next year or shortly thereafter.

Those Spanos are money grubbing grubbers. LOL

So if YOU get to become a fan of MY team, what can i say?

EAT my SWEET WHEY and DIE.... LOL

---------------------

randall... gets down... kill death and hang around to root for the
home team...


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JRStern  
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 More options 9 Nov, 22:16
Newsgroups: alt.support.skin-diseases.psoriasis
From: JRStern <JRSt...@foobar.invalid>
Date: Mon, 09 Nov 2009 14:16:35 -0800
Local: Mon 9 Nov 2009 22:16
Subject: Re: The MOTHER of all GUT Posts? GPR43 (FFAR2) TLR's B-vits = LONG LIFE
On Sun, 8 Nov 2009 18:37:28 -0800 (PST), randall <ranhu...@aol.com>
wrote:

>What about w3?  How short is it compared to 6, 9, 12 hike?

That's a point.

>And one of those may look rather familiar to YOU. <W>

>http://groups.google.com/group/alt.support.skin-diseases.psoriasis/ms...

how about that.

>And look at this anti pharma post in a similar B1 thread:
>http://groups.google.com/group/alt.support.skin-diseases.psoriasis/ms...

>Holy Ghost. This is so weird to revisit the ghost of fumaderm.

That's OK, Obama will fix it.

>What I ALSO liked i this thread was the biblical apple references,
>besides the red wine cites.

>Apples and red wine and living for over a 100 years. Yikes...

I've taken a lot of quercetin, back when I got some capsules and tried
those, but didn't see any major results, but I still consume mass
quantities of apples, onions, and tea, three good sources.  Maybe it
helps.  But I still think a mixed bag of such bioflavonids is probably
about the same effectiveness as mass quantities of any one, at least
short of having a custom DNA profile.

>Btw- sorry your LA team couldn't beat the New York team.

Lakers rool.

J.


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