Epigenetic, modifications of DNA and histones, i.e. heritable
alterations in gene expression that do not involve changes in DNA
sequences, are known to be involved in disease. Two important epigenetic
changes that contribute to disease are abnormal methylation patterns of
DNA and modifications of histones in chromatin. Epimutations, such as
the hypermethylation and epigenetic silencing of tumor suppressor genes,
have revealed a new area for cancer treatment. Studies using DNA
methyltransferase inhibitors such as procaine, hydralazine, and RG108
have had promising outcomes against cancer therapy. Melatonin, one of
the most versatile molecules in nature, may hypothetically be involved
in epigenetic regulation. In this review, the potential role of
melatonin in inhibiting DNA methyltransferase and epigenetic regulation
is discussed.

Publication Types:
*  Review